PUBLICATIONS

Bartonella henselae:

Vigil, A., Ortega, R., Jain, A., Nakajima-Sasaki, R., Tan, X., Chomel, B. B., Kasten, R. W., Koehler, J. E., and Felgner, P. L. (2010) Identification of the feline humoral immune response to Bartonella henselae infection by protein microarray, PLoS One 5, e11447.

Borrelia burgdorferi:

Barbour, A. G., Jasinskas, A., Kayala, M. A., Davies, D. H., Steere, A. C., Baldi, P., and Felgner, P. L. (2008) A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi, Infect Immun 76, 3374-3389.

Brucella melitensis:

Liang, L., Leng, D., Burk, C., Nakajima-Sasaki, R., Kayala, M. A., Atluri, V. L., Pablo, J., Unal, B., Ficht, T. A., Gotuzzo, E., Saito, M., Morrow, W. J., Liang, X., Baldi, P., Gilman, R. H., Vinetz, J. M., Tsolis, R. M., and Felgner, P. L. (2010) Large scale immune profiling of infected humans and goats reveals differential recognition of Brucella melitensis antigens, PLoS Negl Trop Dis 4, e673.

Liang, L., Tan, X., Juarez, S., Villaverde, H., Pablo, J., Nakajima-Sasaki, R., Gotuzzo, E., Saito, M., Hermanson, G., Molina, D., Felgner, S., Morrow, W. J., Liang, X., Gilman, R. H., Davies, D. H., Tsolis, R. M., Vinetz, J. M., and Felgner, P. L. (2011) Systems biology approach predicts antibody signature associated with Brucella melitensis infection in humans, J Proteome Res 10, 4813-4824.

Cannella, A. P., Lin, J. C., Liang, L., Atluri, V., Gotuzzo, E., Felgner, P. L., Tsolis, R. M., and Vinetz, J. M. (2012) Serial Kinetics of the Antibody Response against the Complete Brucella melitensis ORFeome in Focal Vertebral Brucellosis, J Clin Microbiol 50, 922-926.

Burkholderia pseudomallei:

Felgner, P. L., Kayala, M. A., Vigil, A., Burk, C., Nakajima-Sasaki, R., Pablo, J., Molina, D. M., Hirst, S., Chew, J. S., Wang, D., Tan, G., Duffield, M., Yang, R., Neel, J., Chantratita, N., Bancroft, G., Lertmemongkolchai, G., Davies, D. H., Baldi, P., Peacock, S., and Titball, R. W. (2009) A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens, Proc Natl Acad Sci U S A 106, 13499-13504.

Tippayawat, P., Saenwongsa, W., Mahawantung, J., Suwannasaen, D., Chetchotisakd, P., Limmathurotsakul, D., Peacock, S. J., Felgner, P. L., Atkins, H. S., Titball, R. W., Bancroft, G. J., and Lertmemongkolchai, G. (2009) Phenotypic and functional characterization of human memory T cell responses to Burkholderia pseudomallei, PLoS Negl Trop Dis 3, e407.

Yang, Z. R., Lertmemongkolchai, G., Tan, G., Felgner, P. L., and Titball, R. (2009) A genetic programming approach for Burkholderia pseudomallei diagnostic pattern discovery, Bioinformatics 25, 2256-2262.

Suwannasaen, D., Mahawantung, J., Chaowagul, W., Limmathurotsakul, D., Felgner, P. L., Davies, H., Bancroft, G. J., Titball, R. W., and Lertmemongkolchai, G. (2011) Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis, J Infect Dis 203, 1002-1011.

Conejero, L., Patel, N., de Reynal, M., Oberdorf, S., Prior, J., Felgner, P. L., Titball, R. W., Salguero, F. J., Bancroft, G. J. (2011) Low-dose exposure of C57BL/6 mice to burkholderia pseudomallei mimics chronic human melioidosis, Am J Pathol 179, 270-280.

Candidemia:

Mochon, A. B., Ye, J., Kayala, M. A., Wingard, J. R., Clancy, C. J., Nguyen, M. H., Felgner, P., Baldi, P., and Liu, H. (2010) Serological profiling of a Candida albicans protein microarray reveals permanent host-pathogen interplay and stage-specific responses during candidemia, PLoS Pathog 6, e1000827.

Chlamydia trachomatis:

Molina, D. M., Pal, S., Kayala, M. A., Teng, A., Kim, P. J., Baldi, P., Felgner, P. L., Liang, X., and de la Maza, L. M. (2010) Identification of immunodominant antigens of Chlamydia trachomatis using proteome microarrays, Vaccine 28, 3014-3024.

Cruz-Fisher MI, Cheng C, Sun G, Pal S, Teng A, Molina DM, Kayala MA, Vigil A, Baldi P, Felgner PL, Liang X, de la Maza LM. (2011) Identification of immunodominant antigens by hybridization a whole Chlamydia trachomatis open reading frame proteome microarray using sera from immunized mice. Infect Immun. 79(1):246-57.

Coxiella burnetii:

Beare, P. A., Chen, C., Bouman, T., Pablo, J., Unal, B., Cockrell, D. C., Brown, W. C., Barbian, K. D., Porcella, S. F., Samuel, J. E., Felgner, P. L., and Heinzen, R. A. (2008) Candidate Q fever serodiagnostic antigens revealed by immunoscreening a Coxiella burnetii protein microarray, Clin Vaccine Immunol. (12):1771-9.

Chen, C., Bouman, T. J., Beare, P. A., Mertens, K., Zhang, G. Q., Russell-Lodrigue, K. E., Hogaboam, J. P., Peters, B., Felgner, P. L., Brown, W. C., Heinzen, R. A., Hendrix, L. R., and Samuel, J. E. (2009) A systematic approach to evaluate humoral and cellular immune responses to Coxiella burnetii immunoreactive antigens, Clin Microbiol Infect 15 Suppl 2, 156-157

Vigil, A., Ortega, R., Nakajima-Sasaki, R., Pablo, J., Molina, D. M., Chao, C. C., Chen, H. W., Ching, W. M., and Felgner, P. L. (2010) Genome-wide profiling of humoral immune response to Coxiella burnetii infection by protein microarray, Proteomics 10, 2259-2269.

Vigil, A., Chen, C., Jain, A., Nakajima-Sasaki, R., Jasinskas, A., Pablo, J., Hendrix, L. R., Samuel, J. E., Felgner, P. L. (2011) Profiling the humoral immune response of acute and chronic Q fever by protein microarray, Mol Cell Proteomics [Epub ahead of print] PMID: 21817167.

Francisella tularensis:

Isherwood, K. E., Titball, R. W., Davies, D. H., Felgner, P. L., and Morrow, W. J. (2005) Vaccination strategies for Francisella tularensis, Adv Drug Deliv Rev 57, 1403-1414.

Eyles, J. E., Unal, B., Hartley, M. G., Newstead, S. L., Flick-Smith, H., Prior, J. L., Oyston, P. C., Randall, A., Mu, Y., Hirst, S., Molina, D. M., Davies, D. H., Milne, T., Griffin, K. F., Baldi, P., Titball, R. W., and Felgner, P. L. (2007) Immunodominant Francisella tularensis antigens identified using proteome microarray. , Proteomics 7, 2172-2183.

Lu, Z., Roche, M. I., Hui, J. H., Unal, B., Felgner, P. L., Gulati, S., Madico, G., and Sharon, J. (2007) Generation and characterization of hybridoma antibodies for immunotherapy of tularemia, Immunol Lett 112, 92-103.

Sundaresh, S., Randall, A., Unal, B., Petersen, J. M., Belisle, J. T., Gill Hartley, M., Duffield, M., Titball, R. W., Davies, D. H., Felgner, P. L., and Baldi, P. (2007) From protein microarrays to diagnostic antigen discovery: a study of the pathogen Francisella tularensis, Bioinformatics 23, i508-i518.

HPV:

Luevano, M., Bernard, H. U., Barrera-Saldana, H. A., Trevino, V., Garcia-Carranca, A., Villa, L. L., Monk, B. J., Tan, X., Davies, D. H., Felgner, P. L., and Kalantari, M. (2010) High-throughput profiling of the humoral immune responses against thirteen human papillomavirus types by proteome microarrays, Virology 405(1):31-40.

HSV:

Kalantari-Dehaghi, M., Chun, S., Chentoufi, A., Pablo, J., Liang, L., Dasgupta, G., Molina, D. M., Jasinskas, A., Nakajima-Sasaki, R., Felgner, J., Hermanson, G., Benmohamed, L., Felgner, P. L., and Davies, D. H. (2012) Discovery of potential diagnostic and vaccine antigens in herpes simplex virus-1 and -2 by proteome-wide antibody profiling, J Virol.

Dasgupta, G., Chentoufi, A. A., Kalantari, M., Falatoonzadeh, P., Chun, S., Lim, C. H., Felgner, P. L., Davies, D. H., and Benmohamed, L. (2012) Immunodominant “Asymptomatic” Herpes Simplex Virus Type 1 and Type 2 Protein Antigens Identified by Probing Whole ORFome Microarrays By Serum Antibodies From Seropositive Asymptomatic Versus Symptomatic Individuals, J Virol.

Malaria:

Doolan, D. L., Aguiar, J. C., Weiss, W. R., Sette, A., Felgner, P. L., Regis, D. P., Quinones-Casas, P., Yates, J. R., 3rd, Blair, P. L., Richie, T. L., Hoffman, S. L., and Carucci, D. J. (2003) Utilization of genomic sequence information to develop malaria vaccines, J Exp Biol 206, 3789-3802.

Doolan, D. L., Mu, Y., Unal, B., Sundaresh, S., Hirst, S., Valdez, C., Randall, A., Molina, D., Liang, X., Freilich, D. A., Oloo, J. A., Blair, P. L., Aguiar, J. C., Baldi, P., Davies, D. H., and Felgner, P. L. (2008) Profiling humoral immune responses to P. falciparum infection with protein microarrays, Proteomics 8, 4680-4694.

Crompton, P. D., Kayala, M. A., Traore, B., Kayentao, K., Ongoiba, A., Weiss, G. E., Molina, D. M., Burk, C. R., Waisberg, M., Jasinskas, A., Tan, X., Doumbo, S., Doumtabe, D., Kone, Y., Narum, D. L., Liang, X., Doumbo, O. K., Miller, L. H., Doolan, D. L., Baldi, P., Felgner, P. L., and Pierce, S. K. (2010) A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray, Proc Natl Acad Sci U S A 107, 6958-6963.

Trieu, A., Kayala, M. A., Burk, C., Molina, D. M., Freilich, D. A., Richie, T. L., Baldi P., Felgner, P. L., Doolan, D. L. (2011) Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens, Mol Cell Proteomics, [Epub in press] PMID: 21628511.

Tan, X., Traore, B., Kayentao, K., Ongoiba, A., Doumbo, S., Waisberg, M., Doumbo, O. K., Felgner, P. L., Fairhurst, R. M., and Crompton, P. D. (2011) Hemoglobin S and C heterozygosity enhances neither the magnitude nor breadth of antibody responses to a diverse array of Plasmodium falciparum antigens, J Infect Dis 204, 1750-1761.

Nnedu, O. N., O’Leary, M. P., Mutua, D., Mutai, B., Kalantari-Dehaghi, M., Jasinskas, A., Nakajima-Sasaki, R., John-Stewart, G., Otieno, P., Liang, X., Waitumbi, J., Kimani, F., Camerini, D., Felgner, P. L., Walson, J. L., and Vigil, A. (2011) Humoral immune responses to Plasmodium falciparum among HIV-1-infected Kenyan adults, Proteomics. Clinical applications 5, 613-623.

Barry, A. E., Trieu, A., Fowkes, F. J., Pablo, J., Kalantari-Dehaghi, M., Jasinskas, A., Tan, X., Kayala, M. A., Tavul, L., Siba, P. M., Day, K. P., Baldi, P., Felgner, P. L., Doolan, D. L. (2011) The stability and complexity of antibody responses to the major surface antigen of Plasmodium falciparum are associated with age in a malaria endemic area, Mol Cell Proteomics, [Epub in press] PMID: 21825279.

Mycobacterium tuberculosis:

Kunnath-Velayudhan, S., Salamon, H., Wang, H. Y., Davidow, A. L., Molina, D. M., Huynh, V. T., Cirillo, D. M., Michel, G., Talbot, E. A., Perkins, M. D., Felgner, P. L., Liang, X., and Gennaro, M. L. (2010) Dynamic antibody responses to the Mycobacterium tuberculosis proteome, Proc Natl Acad Sci U S A. 107(33):14703-8.

Khan, I. H., Ravindran, R., Krishnan, V. V., Awan, I. N., Rizvi, S. K., Saqib, M. A., Shahzad, M. I., Tahseen, S., Ireton, G., Goulding, C. W., Felgner, P., DeRiemer, K., Khanum, A., and Luciw, P. A. (2011) Plasma antibody profiles as diagnostic biomarkers for tuberculosis, Clin Vaccine Immunol 18, 2148-2153.

Orthopoxvirus:

Davies, D. H., Liang, X., Hernandez, J. E., Randall, A., Hirst, S., Mu, Y., Romero, K. M., Nguyen, T. T., Kalantari-Dehaghi, M., Crotty, S., Baldi, P., Villarreal, L. P., and Felgner, P. L. (2005) Profiling the humoral immune response to infection by using proteome microarrays: High-throughput vaccine and diagnostic antigen discovery, Proc Natl Acad Sci U S A 102, 547-552.

Crotty, S., Felgner, P., Davies, H., Glidewell, J., Villarreal, L., and Ahmed, R. (2003) Cutting edge: long-term B cell memory in humans after smallpox vaccination, J Immunol 171, 4969-4973.

Davies, D. H., McCausland, M. M., Valdez, C., Huynh, D., Hernandez, J. E., Mu, Y., Hirst, S., Villarreal, L., Felgner, P. L., and Crotty, S. (2005) Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice, J Virol 79, 11724-11733.

Davies, D. H., Molina, D. M., Wrammert, J., Miller, J., Hirst, S., Mu, Y., Pablo, J., Unal, B., Nakajima-Sasaki, R., Liang, X., Crotty, S., Karem, K. L., Damon, I. K., Ahmed, R., Villarreal, L., and Felgner, P. L. (2007) Proteome-wide analysis of the serological response to vaccinia and smallpox, Proteomics 7, 1678-1686.

Weaver, J. R., Shamim, M., Alexander, E., Davies, D. H., Felgner, P. L., and Isaacs, S. N. (2007) The identification and characterization of a monoclonal antibody to the vaccinia virus E3 protein, Virus Res 130, 269-274.

Benhnia, M. R., McCausland, M. M., Su, H. P., Singh, K., Hoffmann, J., Davies, D. H., Felgner, P. L., Head, S., Sette, A., Garboczi, D. N., and Crotty, S. (2008) Redundancy and plasticity of neutralizing antibody responses are cornerstone attributes of the human immune response to the smallpox vaccine, J Virol 82, 3751-3768.

Davies, D. H., Wyatt, L. S., Newman, F. K., Earl, P. L., Chun, S., Hernandez, J. E., Molina, D. M., Hirst, S., Moss, B., Frey, S. E., and Felgner, P. L. (2008) Antibody profiling by proteome microarray reveals the immunogenicity of the attenuated smallpox vaccine modified vaccinia virus ankara is comparable to that of Dryvax, J Virol 82, 652-663.

Jing, L., Davies, D. H., Chong, T. M., Chun, S., McClurkan, C. L., Huang, J., Story, B. T., Molina, D. M., Hirst, S., Felgner, P. L., and Koelle, D. M. (2008) An extremely diverse CD4 response to vaccinia virus in humans is revealed by proteome-wide T-cell profiling, J Virol 82, 7120-7134.

Sette, A., Moutaftsi, M., Moyron-Quiroz, J., McCausland, M. M., Davies, D. H., Johnston, R. J., Peters, B., Rafii-El-Idrissi Benhnia, M., Hoffmann, J., Su, H. P., Singh, K., Garboczi, D. N., Head, S., Grey, H., Felgner, P. L., and Crotty, S. (2008) Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities, Immunity 28, 847-858.

Jing, L., McCaughey, S. M., Davies, D. H., Chong, T. M., Felgner, P. L., De Rosa, S. C., Wilson, C. B., and Koelle, D. M. (2009) ORFeome approach to the clonal, HLA allele-specific CD4 T-cell response to a complex pathogen in humans, J Immunol Methods 347, 36-45.

Tan, X., Chun, S., Pablo, J., Felgner, P., Liang, X., and Davies, D. H. (2012) Failure of smallpox vaccine to take in vaccinia-naive individuals is related to differences in antibody profiles before vaccination, not after, Clin Vaccine Immunol.

Hermanson, G., Chun, S., Felgner, J., Tan, X., Pablo, J., Nakajima-Sasaki, R., Molina, D. M., Felgner, P. L., Liang, X., and Davies, D. H. (2012) Measurement of antibody responses to Modified Vaccinia virus Ankara (MVA) and Dryvax((R)) using proteome microarrays and development of recombinant protein ELISAs, Vaccine 30, 614-625.

Pemphigus vulgaris:

Kalantari-Dehaghi, M., Molina, D. M., Farhadieh, M., Morrow, W. J., Liang, X., Felgner, P. L., Grando, S. A. (2011) New targets of pemphigus vulgaris antibodies identified by protein array technology, Exp Dermatol 20, 154-156.

Schistosomiasis:

Driguez, P., Doolan, D. L., Loukas, A., Felgner, P. L., and McManus, D. P. (2010) Schistosomiasis vaccine discovery using immunomics, Parasit Vectors 3, 4.

Salmonella:

Lee, S. J., Liang, L., Juarez, S., Nanton, M. R., Gondwe, E. N., Msefula, C. L., Kayala, M. A., Necchi, F., Heath, J. N., Hart, P., Tsolis, R. M., Heyderman, R. S., Maclennan, C. A., Felgner, P. L., Davies, D. H., and McSorley, S. J. (2012) Identification of a common immune signature in murine and human systemic Salmonellosis, Proc Natl Acad Sci U S A.

Toxoplasmosis:

Doskaya, M., Kalantari-Dehaghi, M., Walsh, C. M., Hiszczynska-Sawicka, E., Davies, D. H., Felgner, P. L., Larsen, L. S., Lathrop, R. H., Hatfield, G. W., Schulz, J. R., Guruz, Y., and Jurnak, F. (2007) GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine, Vaccine 25, 1824-1837.

Liang, L., Doskaya, M., Juarez, S., Caner, A., Jasinskas, A., Tan, X., Hajagos, B. E., Bradley, P. J., Korkmaz, M., Guruz, Y., Felgner, P. L., and Davies, D. H. (2011) Identification of potential serodiagnostic and subunit vaccine antigens by antibody profiling of toxoplasmosis cases in Turkey, Mol Cell Proteomics 10, M110 006916.

General:

Sundaresh, S., Doolan, D. L., Hirst, S., Mu, Y., Unal, B., Davies, D. H., Felgner, P. L., and Baldi, P. (2006) Identification of humoral immune responses in protein microarrays using DNA microarray data analysis techniques, Bioinformatics 22, 1760-1766.

Regis, D. P., Dobano, C., Quinones-Olson, P., Liang, X., Graber, N. L., Stefaniak, M. E., Campo, J. J., Carucci, D. J., Roth, D. A., He, H., Felgner, P. L., and Doolan, D. L. (2008) Transcriptionally active PCR for antigen identification and vaccine development: in vitro genome-wide screening and in vivo immunogenicity, Mol Biochem Parasitol 158, 32-45.

Vigil, A., Davies, D. H., and Felgner, P. L. (2010) Defining the humoral immune response to infectious agents using high-density protein microarrays, Future Microbiol 5, 241-251.

Molina DM, Liang X, Morrow WJW. Use of High-Throughput Proteomic Arrays for the Discovery of Disease-Associated Molecules. Biomarkers in Drug Development: A Handbook of Practice, Application, and Strategy. 2010. Wiley. Michael R. Bleavins (Editor), Claudio Carini (Editor), Mallé Jurima-Romet (Editor), Ramin Rahbari (Editor)

Noroozi, Z., Kido, H., Peytavi, R., Nakajima-Sasaki, R., Jasinskas, A., Micic, M., Felgner, P. L., Madou, M. J. (2011) A multiplexed immunoassay system based upon reciprocating centrifugal microfluidics, Rev Sci Instrum 82, 064303.

Williams, T. N. (2011) How do hemoglobins s and C result in malaria protection?, J Infect Dis 204, 1651-1653.